More than five years since COVID-19 was declared a pandemic, the virus continues to evolve, producing new variants that challenge public health efforts. The latest variant to gain traction, LP.8.1, is increasing in prevalence across multiple countries. But should we be concerned? Let’s explore what scientists have uncovered so far.
The Emergence of LP.8.1
Detected in July 2024, LP.8.1 is a descendant of omicron, specifically evolving from KP.1.1.3, which itself stems from JN.1, a subvariant that led to widespread infections globally in late 2023 and early 2024.
The World Health Organization (WHO) classified LP.8.1 as a variant under monitoring in January 2025 due to its increasing presence worldwide and genetic changes that might enhance its transmission. But despite its rapid spread, it has not been labeled a variant of concern, meaning its potential risks remain relatively low.
What Makes LP.8.1 Different?
LP.8.1 carries six mutations in its spike protein, which facilitates the virus’s ability to bind to human cells. One specific mutation, V445R, has been linked to increased transmission and stronger binding to lung cells, making it potentially more contagious than other circulating variants.
Despite these genetic differences, there’s no evidence to suggest LP.8.1 causes more severe symptoms than previous variants. WHO experts have assessed its additional public health risk as low, reassuring that its overall impact on the pandemic’s trajectory is minimal for now.
A Growing Presence Around the World
While LP.8.1 may not pose a heightened risk, it is still spreading rapidly in multiple regions:
- Australia: Close to 1 in 5 COVID cases in New South Wales are linked to LP.8.1.
- United Kingdom: The variant makes up around 60% of cases, fueling concerns of a potential new wave.
- United States: LP.8.1 is responsible for 55% of reported cases.
In Australia alone, 45,000 new COVID cases have been recorded so far this year, although many infections likely go unreported due to declining test rates.
Will Vaccines Hold Up Against LP.8.1?
Fortunately, current COVID vaccines, including the latest JN.1 booster shots, are expected to provide strong protection against symptomatic and severe disease caused by LP.8.1.
However, given its classification as a variant under monitoring, WHO member countries will continue to study its behavior—including any potential ability to evade immunity.
The Bottom Line
While LP.8.1 is spreading globally, the overall risk to public health remains low at this stage. However, COVID-19 continues to be a serious concern, especially for vulnerable populations. As new variants emerge, vigilance, updated vaccinations, and ongoing research remain essential in managing the virus.
What are your thoughts on LP.8.1’s rise? Are you keeping up with the latest vaccine updates? Let’s discuss.
